MD生物科学/髓磷脂蛋白脂蛋白（PLP 139-151）/15毫克/301008
商品编号：
301008
品牌：
mdbiosciences
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Overview
- Literature/Support
Overview
Overview:
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the disease are focal areas of demyelination and inflammation, however the pathogenesis is unclear.
Although no animal model thus far establishes all facets of human MS, Experimental Autoimmune Encephalomyelitis (EAE) represents the model most studied for the disease. Initially brain homogenates were used as antigens for immunization. Today, myelin related proteins or peptides are used in the disease.
Literature/Support
Literature/Support/Publications:
Myelin Proteolipid Protein Insert (PDF)
References/Citations: | How Proteolipid protein (PLP) was used: |
| The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders M Hultqvist, K S Nandakumar, U Björklund, and R Holmdahl Ann Rheum Dis, Jan 2009; 68: 130 - 135. | Proteolipid protein (PLP) was used to induce EAE in SJL mice by subcutaneous injection.On day 0, 125 ug PLP/300 ug CFA per animal was used for induction and a supplemental immunostimulation with 20 ug/kg pertussis toxin was performed on day 0 and after 48 hrs. |
品牌介绍
MD Biosciences 是针对药物和诊断资产开发的临床前，转化和临床阶段合同研究服务的供应商。通过AAALAC 认证，符合 GLP 的 CLIA 设施，在广泛的治疗领域提供服务和产品，包括炎性疾病，自身免疫，神经病学，肿瘤学，新陈代谢和疼痛。为了在每个专业领域提供最优质的产品和专业知识并优化研究，设有 4 个独立的部门：MD Biosciences炎症/免疫学服务、MD Biosciences神经病学发现服务、MD Biosciences组织病理学服务和MD Bioproducts。
